Kinase signalling networks in Parkinson's disease
Our research aims to uncover the fundamental mechanisms that underlie Parkinson's disease and exploit this knowledge for novel therapeutics. We are particularly interested in how human mutations in the PINK1 kinase lead to dopaminergic neurodegeneration. We have discovered the key substrates of PINK1 including ubiquitin, and our work has placed PINK1 at the heart of a mitochondrial quality control pathway vital for neuronal survival.
Keywords
PINK1 / protein kinase / phosphorylation / Parkin / ubiquitin / Rab GTPases / Parkinson's disease