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EMBO Young Investigator

Miratul Muqit

University, Dundee | United Kingdom

YIP 2017

Kinase signalling networks in Parkinson's disease

Our research aims to uncover the fundamental mechanisms that underlie Parkinson's disease and exploit this knowledge for novel therapeutics. We are particularly interested in how human mutations in the PINK1 kinase lead to dopaminergic neurodegeneration. We have discovered the key substrates of PINK1 including ubiquitin, and our work has placed PINK1 at the heart of a mitochondrial quality control pathway vital for neuronal survival.

Keywords: PINK1 / protein kinase / phosphorylation / Parkin / ubiquitin / Rab GTPases / Parkinson's disease

Subject area(s): Neuroscience | Proteins & Biochemistry | Signal Transduction