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EMBO Member

Moritz Helmstaedter

MPI für Hirnforschung, Frankfurt | Germany

EMBO 2026

Connectomics of the mammalian brain

We use 3D electron microscopy and AI-based image analysis to map the mammalian cerebral cortex, the most complex network known. We study how cortical circuits evolve across species, from mouse to human, and develop connectomic screening for experience- and disease-related circuit changes. We aim to reveal the circuit architecture behind cognition (prediction, long-term memory) and identify its pathological alterations as connectopathies.

Keywords: Neuronal circuits / connectomics / AI / sensory perception / electron microscopy / psychiatric disease / brain / connectopathies

Subject area(s): Cell & Tissue Architecture | Development | Neuroscience

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