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EMBO Member

Nadine Vastenhouw

University, Lausanne | Switzerland

EMBO 2025

Transcriptional regulation in vertebrate embryos

We aim to understand how the transcriptional machinery and chromatin template are brought together in time and space to robustly regulate transcription. As a model we use the maternal-to-zygotic transition in zebrafish embryos, which is the time when transcription begins and embryos take control of their own development. We take a multidisciplinary approach, including genomics, genetics, cell biology, microscopy, and biophysics.

Keywords: Transcription / zebrafish / zygotic genome activation / phase separation / condensates / nuclear organization / chromatin

Subject area(s): Chromatin & Transcription | Development | Proteins & Biochemistry

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