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EMBO Member

Nica Borgese

Istituto di Neuroscienze, Vedano al Lambro | Italy

EMBO 2011

Biogenesis of the ER in mammalian cells

My group investigates various aspects of the biology of the mammalian endoplasmic reticulum. We have been particularly interested in characterizing post-translational insertion mechanisms of tail-anchored proteins and in transmembrane domain-dependent sorting of membrane proteins at the ER-Golgi interface. Another research line concerns the mechanisms by which the ER regulates its size and architecture in response to an altered load of either normal or disease-linked membrane proteins.

Keywords: Endoplasmic reticulum / membrane biogenesis / membrane traffic / protein targeting / tail-anchored proteins

Subject area(s): Membranes & Transport | Neuroscience | Proteins & Biochemistry