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EMBO Member

Nicolas Thomä

University of Bern | Switzerland

EMBO 2015

Structure and function of macromolecular machines

The lab uses an integrated approach to study the structure and function of large macromolecular machines engaged in genome maintenance. We work on cullin-RING ubiquitin ligases in DNA repair examining the mechanisms through which they are regulated. A further focus is on telomeres, their architectures and ways in which telomeres signal to DNA repair systems.

Keywords: Structural biology / genome stability / ubiquitination / thalidomide / DNA repair

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Structural Biology & Biophysics