How infection history regulates immune responses
The focus of my research lies on deciphering how the infection history of an individual shapes its immune responses with respect to subsequent challenge with another pathogen or the susceptibility to autoimmunity. We employ in-vivo animal models, cellular assays and genome-scale approaches to investigate infection-induced changes in the immune system, especially in the effector and regulatory T cell compartments.
Keywords
Immune regulation / regulatory T cells / host-pathogen interaction / adaptive immunity / checkpoint inhibitors