Human genome variation in health and disease
Common, complex conditions such as cardiovascular, inflammatory and immune diseases can be considered as extremes of a broad spectrum of phenotypic variation that is also seen in healthy individuals. Our group is interested in understanding how genetic factors determine such phenotypic variation, using large-scale genome scans including genome sequencing data, epigenetic profiling and molecular traits such as gene expression and metabolomics.
Keywords
Human genetics / genome sequencing / biobanks / cardiometabolic traits / immune traits