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EMBO Member

Nils-Göran Larsson

Karolinska Institutet, Stockholm | Sweden

EMBO 2012

Regulation of mtDNA expression in disease & ageing

My laboratory is focused on studies of the role for mtDNA mutations in pathology and ageing and I also have a strong interest in molecular mechanisms governing germ line transmission of mtDNA. In addition, mechanistic studies are performed to understand the molecular machinery for replication and transcription of mtDNA and mitochondrial translational regulation, by using biochemistry combined with mouse and fly genetics.

Keywords: Mitochondrial DNA / ageing / mitochondrial transcription / mitochondrial disease / mitochondrial translation

Subject area(s): Cellular Metabolism | Genome Stability & Dynamics | Molecular Medicine