EMBO Member
Nils-Göran Larsson
EMBO 2012
Karolinska Institutet, Stockholm, Sweden
Regulation of mtDNA expression in disease & ageing
My laboratory is focused on studies of the role for mtDNA mutations in pathology and ageing and I also have a strong interest in molecular mechanisms governing germ line transmission of mtDNA. In addition, mechanistic studies are performed to understand the molecular machinery for replication and transcription of mtDNA and mitochondrial translational regulation, by using biochemistry combined with mouse and fly genetics.
Keywords
Mitochondrial DNA / ageing / mitochondrial transcription / mitochondrial disease / mitochondrial translation