National University of Ireland, Galway | Ireland
EMBO 2003 | YipC 08–12 | GinC 19–
We are interested in the maintenance of the integrity of the human genome, with a particular focus on newly identified partners of the central regulators of genome stability, ATM and ATR, as well as 53BP1, a regulator of DSB repair. Our work identifies novel mechanisms of relevance to tumour suppression with likely impact in diagnoses and therapeutic interventions in oncology.
Keywords: Sensing DNA damage / DNA repair / cell cycle regulation / biochemistry of checkpoint proteins / cancer biology