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EMBO Member

Noel F. Lowndes

National University of Ireland, Galway | Ireland

EMBO 2003 | YipC 08–12 | GinC 19–22

Mechanisms of genome stability in human cells

We are interested in the maintenance of the integrity of the human genome, with a particular focus on newly identified partners of the central regulators of genome stability, ATM and ATR, as well as 53BP1, a regulator of DSB repair. Our work identifies novel mechanisms of relevance to tumour suppression with likely impact in diagnoses and therapeutic interventions in oncology.

Keywords: Sensing DNA damage / DNA repair / cell cycle regulation / biochemistry of checkpoint proteins / cancer biology

Subject area(s): Cell Cycle | Chromatin & Transcription | Genome Stability & Dynamics