Single-molecule studies of replication
My group focuses on understanding the key cellular process of nucleic acid replication from a biophysical perspective in viral, bacterial, and eukaryotic systems. We perform our studies both using purified components and inside living cells. To study the dynamic aspects of replication and enhance our mechanistic understanding of this key cellular process, we make use of state-of-the-art biophysics that is highly integrated with biochemistry.
Keywords
DNA replication machinery / chromatin dynamics / yeast replication / in-vitro reconstitution / bacterial replication / virology / single-molecule techniques