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EMBO Member

Olivier Delattre

Institut Curie, Paris | France

EMBO 2011

Genetics and biology of p├Ždiatric cancers

My group focuses on the mechanisms of development of cancer, mainly in the field of p├Ždiatric cancers. We combine genetic approaches to identify germline or somatic mutations and functional approaches based on various cell or animal models. Major interets are in EWS/FLI-1 function in Ewing's sarcoma, ALK activating mutation in neuroblastoma and SMARCB1 inactivating mutations in rhabdoid tumours.

Keywords: Genetic alterations / pediatric cancer / EWS / FLI / SMARCB1 / ALK

Subject area(s): Differentiation & Death | Genome Stability & Dynamics | Molecular Medicine