Wiring and remodeling of neural circuits
The mechanisms by which our brain is wired during development are still largely unknown. We utilize the genetic power of Drosophila to study wiring and remodeling of developing neural circuits at the molecular level. Neuronal remodeling is critical for sculpting mature neural circuits and when defective, it is implicated in a wide range of neuropsychiatric disorders including autism and schizophrenia.
Keywords
neurodevelopment / neuronal pruning / Drosophila / neuronal remodeling / actin cytoskeleton / neuro-glia interactions / nitric oxide signaling / synapse