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EMBO Member

Owen J. Sansom

Cancer Research UK Scotland Institute, Glasgow | United Kingdom

EMBO 2024

Colorectal cancer and Wnt signalling

Our group examines the molecular mechanisms underpinning colorectal cancer initiation, progression, response to therapy, and metastasis. To this end, we use state-of-the-art preclinical models harbouring key driver mutations. Our overarching goals are to identify early-stage diagnostic biomarkers and develop stage- and subtype-specific targeted therapies.

Keywords: Adenomatous Polyposis Coli / colorectal cancer / MTOR / neutrophils / models of disease / stem cell competition / intestine

Subject area(s): Signal Transduction | Molecular Medicine | Differentiation & Death