EMBO Young Investigator
CABIMER, Sevilla | Spain
Breaks in the DNA can be repaired by two major and alternative mechanisms that compete for the same substrate, namely homologous recombination and non-homologous end-joining. In our laboratory we investigate how the choice between both repair pathways is made, its relevance for cellular and organismal survival and disease, and its potential as a therapeutic target for the treatment of cancer and some genetically inherited disorders.
Keywords: Homologous recombination / non-homologous end-joining / DNA repair / DNA double strand breaks / cancer