The regulation of DNA double strand break repair
Breaks in the DNA can be repaired by two major and alternative mechanisms that compete for the same substrate, namely homologous recombination and non-homologous end-joining. In our laboratory we investigate how the choice between both repair pathways is made, its relevance for cellular and organismal survival and disease, and its potential as a therapeutic target for the treatment of cancer and some genetically inherited disorders.
Keywords
Homologous recombination / non-homologous end-joining / DNA repair / DNA double strand breaks / cancer