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EMBO Member

Paola Picotti

ETH, Zurich | Switzerland

EMBO 2022

Structural systems biology of neurodegeneration

Our group applies system-level analyses and biochemical tools to study the molecular bases of protein aggregation diseases. A main strength of the lab is the development of mass spectrometry-based proteomics approaches. Specifically, we have developed and constantly improve methods for the in-situ, proteome-wide analysis of protein structures and their alterations as a global readout of regulatory cellular events.

Keywords: Structural proteomics / mass spectrometry / systems biology / protein aggregation / Parkinson's disease

Subject area(s): Genomic & Computational Biology | Molecular Medicine | Proteins & Biochemistry | Structural Biology & Biophysics | Systems Biology