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EMBO Member

Paolo Comoglio

Istituto Firc di Oncologia Molecolare, Milano | Italy

EMBO 1989

The MET oncogene: a driver for cancer metastasis

investigation of the involvement of genetic alterations affecting the MET oncogene in multiple, still unexplored areas of cancer biology and therapy. We aim to provide the mechanistic explanation of how known and novel MET genetic alterations impact on cancer onset and progression to the invasive-metastatic phenotype. We aim then to define the therapeutic efficacy of MET inhibitors, including antibodies and novel chemical molecules.

Keywords: Growth factor receptors / signal transduction / oncogenes / MET / target therapy

Subject area(s): Cell Cycle | Molecular Medicine | Signal Transduction