Synaptic and mitochondrial dysfunction in PD
My group tackles the unresolved question how neurons communicate in our brain and how the process of neuronal transmission is disrupted in neuronal disease, with a special emphasis on Parkinson's disease. Our discoveries have led to several new drug targets and collaborations, but most of all they have inspired a new generation of researchers that have emerged from my lab who are continuing this mission at leading institutions around the globe.
Keywords
Parkinson's disease / synaptic homeostasis / Drosophila / induced pluripotent stem cells / autophagy / mitochondria