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EMBO Member

Paul Lehner

University of Cambridge, Cambridge | United Kingdom

EMBO 2019

Viral silencing and immune evasion pathways

My lab is interested in understanding how viruses manipulate the host immune system. We use unbiased genetic and proteomic approaches to uncover novel virus-host interactions such as resistance factors of HIV. Our recent discovery of the 'Human Silencing Hub' (HUSH) complex, a novel epigenetic repressor complex that assembles H3K9me3 heterochromatin, explains how the host silences newly integrated retroviruses and mobile endogenous retrotransposons.

Keywords: Viral immune evasion / epigenetic repressor complex / heterochromatin / lentiviral restriction / ubiquitin E3 ligases / forward genetic screens

Subject area(s): Chromatin & Transcription | Immunology | Microbiology, Virology & Pathogens

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