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EMBO Member

Paul Lehner

University of Cambridge, Cambridge | United Kingdom

EMBO 2019

Viral silencing and immune evasion pathways

We study how viruses manipulate the host immune system using unbiased genetic and proteomic approaches to uncover novel virus-host interactions. Our discovery of the 'Human Silencing Hub' (HUSH) complex, a novel epigenetic repressor complex that assembles repressive H3K9me3 heterochromatin, explains how the host silences integrated retroviruses and retrotransposons and protects the genome from the reverse flow of genetic information.

Keywords: Viral immune evasion / epigenetic repressor complex / heterochromatin / lentiviral restriction / ubiquitin E3 ligases / forward genetic screens / HUSH

Subject area(s): Chromatin & Transcription | Immunology | Microbiology, Virology & Pathogens