Viral silencing and immune evasion pathways
We study how viruses manipulate the host immune system using unbiased genetic and proteomic approaches to uncover novel virus-host interactions. Our discovery of the 'Human Silencing Hub' (HUSH) complex, a novel epigenetic repressor complex that assembles repressive H3K9me3 heterochromatin, explains how the host silences integrated retroviruses and retrotransposons and protects the genome from the reverse flow of genetic information.
Keywords
Viral immune evasion / epigenetic repressor complex / heterochromatin / lentiviral restriction / ubiquitin E3 ligases / forward genetic screens / HUSH