Cellular consequences of genetic variation
What makes each human individual different and the diversity of life on earth are, to some extent, determined by differences in DNA. However, it remains unclear how these DNA differences manifest in a variety of shapes, capabilities and even different propensity to disease. My group's goal is to develop comprehensive models of how DNA changes result in differences in biomolecules, their interactions and ultimately different traits.
Keywords
Phosphorylation / kinases / genetic variants / computational models / protein interactions / cellular networks