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EMBO Member

Peter J. Cullen

University, Bristol | United Kingdom

EMBO 2021

Cargo sorting in the endosomal-lysosomal network

Our lab seeks to achieve a thorough mechanistic understanding of how integral proteins and associated proteins and lipids are sorted and transported through the endosomal-lysosomal network. We apply this knowledge to understand and interpret the underlying deregulation of endosomal-lysosomal cargo sorting observed in human diseases, including neurological disorders, cardiovascular disease, metabolic diseases, and host-pathogen interactions.

Keywords: Endosomes / lysosomes / membrane trafficking / retromer / retriever / sorting nexins / neurodegeneration / phosphoinositides

Subject area(s): Membranes & Transport | Molecular Medicine | Neuroscience | Proteins & Biochemistry