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EMBO Member

Peter J. Ratcliffe

University of Oxford | United Kingdom

EMBO 2006

Hypoxia signalling

My laboratory works on understanding the mechanisms by which cells sense and signal hypoxia. Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a central physiological challenge for all large animals. Hypoxia is an important component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia.

Keywords: Oxygen sensing / hypoxia signalling / angiogenesis / regulation of HIF by prolyl hydroxylases / von Hippel-Lindau tumour suppressor (VHL)

Subject area(s): Cellular Metabolism | Molecular Medicine | Signal Transduction