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EMBO Member

Peter ten Dijke

University Medical Centre, Leiden | Netherlands

EMBO 2016

TGF-beta family signaling in diseases

My group investigates the molecular mechanisms by which TGF-beta family members elicit their cellular effects via (co-)receptors and intracellular SMAD effectors, and how subverted TGF-beta family signaling is involved in cancer, vascular and bone diseases. Our long-term aim is to translate our findings towards novel treatment modalities.

Keywords: TGF-beta / bone morphogenetic protein / receptor / SMAD / signal transduction / transcription / cancer / angiogenesis

Subject area(s): Differentiation & Death | Molecular Medicine | Signal Transduction