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EMBO Member

Philip Avner

EMBL Rome, Monterotondo | Italy

EMBO 2005

Epigenetics and genetics in mouse development

Our laboratory is working on epigenetics using X-inactivation in the mouse as an experimental paradigm. Studies are centred on the initiation onset step and the role of the X-inactivation centre, the master regulator region. Ongoing genetic studies explore the role of epistasis in the mouse using chromosome substitution strains.

Keywords: Epigenetics / X inactivation / mouse genetics / multigenic inheritance / type 1 diabetes / chromatin / stem cells

Subject area(s): Chromatin & Transcription | Development | RNA