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EMBO Member

Philippe Chavrier

Institut Curie, Paris | France

EMBO 2014

Cell biology of tumor cell invasion

Remodeling of the extracellular matrix by tumor cells requires formation of actin-based invadopodia, where the trans-membrane matrix metalloproteinase MT1-MMP accumulates. Our group uses breast tumor cell lines and an intraductal xenograft mouse model to investigate the mechanism underlying MT1-MMP exocytosis during the formation of invadopodia and how this is influenced by the composition and biophysical properties of the extracellular matrix.

Keywords: Tumor cell invasion / matrix metalloproteinase / membrane traffic / exocytosis / cell polarity

Subject area(s): Cell & Tissue Architecture | Membranes & Transport | Molecular Medicine