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Portrait of Philippe Pasero

EMBO Member

Philippe Pasero

EMBO 2024

Former EMBO Young Investigator (2007)

Institut de Génétique Humaine, Montpellier, France

Cellular responses to replication stress

My lab investigates the origin and the consequences of replication stress in yeast and human cells using a combination of single-molecule imaging and genome-wide approaches. Our main research interests include transcription-replication conflicts and R-loops, fork remodeling by SMC complexes, checkpoint signaling, and activation of the innate immune response by cytosolic DNA released from stressed replication forks.

Replication stress / R-loops / transcription-replication conflicts / SMC complexes / genomic instability / checkpoints / inflammation / cancer