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EMBO Member

Philippe Pasero

Institut de Génétique Humaine, Montpellier | France

EMBO 2024

Cellular responses to replication stress

My lab investigates the origin and the consequences of replication stress in yeast and human cells using a combination of single-molecule imaging and genome-wide approaches. Our main research interests include transcription-replication conflicts and R-loops, fork remodeling by SMC complexes, checkpoint signaling, and activation of the innate immune response by cytosolic DNA released from stressed replication forks.

Keywords: Replication stress / R-loops / transcription-replication conflicts / SMC complexes / genomic instability / checkpoints / inflammation / cancer

Subject area(s): Cell Cycle | Genome Stability & Dynamics | Genomic & Computational Biology