
EMBO Member
Philippe Pasero
EMBO 2024
Former EMBO Young Investigator (2007)
Cellular responses to replication stress
My lab investigates the origin and the consequences of replication stress in yeast and human cells using a combination of single-molecule imaging and genome-wide approaches. Our main research interests include transcription-replication conflicts and R-loops, fork remodeling by SMC complexes, checkpoint signaling, and activation of the innate immune response by cytosolic DNA released from stressed replication forks.
Keywords
Replication stress / R-loops / transcription-replication conflicts / SMC complexes / genomic instability / checkpoints / inflammation / cancer