Ribosome-driven homeostasis and signaling
Our work focuses on understanding how the ribosome functions at a molecular level and how changes in its activity impact ribosome homeostasis, mRNA quality control and the induction of cellular stress responses. We use genetic, genomic, biochemical and structural approaches to explore these questions in mammalian systems. In these studies, we endeavor to bring deep molecular mechanistic insight to these fundamental biological questions.
Keywords
Ribosome / translation / RNA / quality control / ribosome stress / stress responses / homeostasis