Chromatin dynamics in cancer and stem cells
My team aims to understand the basic mechanisms of epigenetic and chromatin regulation and the dynamics of genome organization that ultimately result in the fine control of gene expression. Additionally, we aim to elucidate how alterations of epigenetic regulatory systems contribute to complex diseases such as cancer, and use this information to identify markers for early diagnosis, drug response and targets for efficient therapies.
Keywords
Epigenetics / chromatin / nuclear organization / nucleolus / transcription / non-coding RNA / cancer / stem cells