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EMBO Associate Member

Rajan Sankaranarayanan

Centre for Cellular and Molecular Biology (CCMB), Hyderabad | India

EMBO 2022

Quality control during protein biosynthesis

Our laboratory is interested in understanding unique proofreading mechanisms that are operational in the cell to maintain quality control during translation of the genetic code. We are particularly interested in how D-amino acids are kept away from getting incorporated during protein biosynthesis. We are looking at the mechanistic, physiological and evolutionary role of 'chiral proofreading' systems using both in-vitro and in-vivo approaches.

Keywords: Protein translation / chiral checkpoints / proofreading / eukaryote evolution / structural biology / D-amino acids / RNA / lipid metabolism / tRNA synthetase

Subject area(s): Proteins & Biochemistry | Structural Biology & Biophysics | Evolution & Ecology