EMBO Associate Member
Rajan Sankaranarayanan
EMBO 2022
Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India
Quality control during protein biosynthesis
Our laboratory is interested in understanding unique proofreading mechanisms that are operational in the cell to maintain quality control during translation of the genetic code. We are particularly interested in how D-amino acids are kept away from getting incorporated during protein biosynthesis. We are looking at the mechanistic, physiological and evolutionary role of 'chiral proofreading' systems using both in-vitro and in-vivo approaches.
Keywords
Protein translation / chiral checkpoints / proofreading / eukaryote evolution / structural biology / D-amino acids / RNA / lipid metabolism / tRNA synthetase