EMBO Member

Raymond Kaempfer

Hebrew University, Jerusalem | Israel

EMBO 1982

Regulation of the inflammatory cytokine response

We (1) investigate how short intragenic RNA elements that activate the RNA-dependent stress kinase PKR regulate inflammatory cytokine and hemoglobin gene expression by controlling mRNA splicing or translation; (2) are developing a novel host-oriented therapeutic approach to protect broadly against toxins, bacterial and viral infections by targeting the B7/CD28 costimulatory axis to attenuate the inflammatory cytokine storm harmful to the host.

Keywords: Translational control / mRNA splicing / cytokine gene regulation / RNA-dependent stress signaling / life-threatening infections / cytokine cascade/storm attenuation / costimulatory receptors

Subject area(s): Immunology | RNA | Signal Transduction