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EMBO Member

Richard Marais

Oncodrug Ltd, Alderley Edge | United Kingdom

EMBO 2009

BRAF and RAS signalling in melanoma.

We study the molecular mechanisms underlying melanomagenesis, with particular emphasis on the role of the RAS/RAF/MEK/ERK pathway. We employ biochemistry, molecular biology, cell biology, structural biology, transgenic models and genetics. A key aim is to translate our basic findings into clinical practice.

Keywords: Cell signalling / BRAF & RAS / melanoma / transgenic models / translational research

Subject area(s): Molecular Medicine | Signal Transduction