Regulation of human immune response
Our research aims at understanding the molecular regulation of the human immune response and the pathogenesis of type 1 diabetes and other human immune-mediated diseases. We have identified novel regulators and discovered molecular mechanisms of human T-cell differentiation and function. Our studies on type 1 diabetes have revealed molecular changes in immune cells very early on during the disease process.
Keywords
T cells / cell differentiation and fate / epigenetics / transcriptional regulation / cell signalling / human immunology / non-coding RNA / type 1 diabetes