Target of rapamycin (TOR) signaling
Our lab uses S. cerevisiae to investigate the structures, functions and regulation of the two, broadly conserved, target of rapamycin (TOR) protein complexes. We use a combination of yeast genetics, cell biology, structural biology, chemical biology and biochemistry approaches and are particularly interested in how TOR complexes form higher order helical structures and how they are regulated downstream of mechanical changes in membrane tension.
Keywords
Signaling / membranes / nutrient sensing / yeast / target of rapamycin (TOR) / membrane tension / lipid metabolism