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EMBO Associate Member

Robert A. Weinberg

Whitehead Institute, Cambridge (MA) | United States

EMBO 2010

Epithelial-mesenchymal transition and the stem-cell state

Our research addresses the mechanisms of malignant progression of carcinoma cells. These neoplastic cells are initially epithelial in nature, but as they pass through the program termed the epithelial-mesenchymal transition, they acquire mesenchymal characteristics that are associated with aggressive, malignant behavior. Partial passage through this program enables these cells to enter into the cancer stem cell state, enabling them to found metastatic colonies at distant anatomical sites.

Keywords: Invasion / metastasis / stem cells / progression / malignancy

Subject area(s): Molecular Medicine | Signal Transduction