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EMBO Associate Member

Robert G. Roeder

Rockefeller University, New York City | United States

EMBO 2003

Transcriptional regulation in animal cells

We are interested in fundamental mechanisms that underlie the regulation of transcription in development, differentiation, homeostasis and oncogenesis. We employ complementary biochemical and cell/mouse-based genetic approaches to study the function, through various co-activators (including Mediator and chromatin modulators), of nuclear hormone receptors, tumor suppressor p53, B cell activators and leukemic fusion proteins in these processes.

Keywords: RNA polymerases / transcription regulatory mechanisms / coactivators / chromatin / nuclear receptors / p53 / B cell differentiation / leukemic fusion proteins

Subject area(s): Chromatin & Transcription | Development