EMBO Associate Member
Robert G. Roeder
EMBO 2003
Rockefeller University, New York City, United States
Transcriptional regulation in animal cells
We are interested in fundamental mechanisms that underlie the regulation of transcription in development, differentiation, homeostasis and oncogenesis. We employ complementary biochemical and cell/mouse-based genetic approaches to study the function, through various co-activators (including Mediator and chromatin modulators), of nuclear hormone receptors, tumor suppressor p53, B cell activators and leukemic fusion proteins in these processes.
Keywords
RNA polymerases / transcription regulatory mechanisms / coactivators / chromatin / nuclear receptors / p53 / B cell differentiation / leukemic fusion proteins