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Portrait of Robert J. Klose

EMBO Member

Robert J. Klose

EMBO 2021

Former EMBO Young Investigator (2011)

University of Oxford, United Kingdom

Epigenetic control of gene expression

In my group we strive to understand how gene expression is controlled by chromatin-based and epigenetic systems, with a focus on CpG island elements in vertebrates. We use a multidisciplinary approach leveraging biochemistry, molecular genetics, genomics, and live-cell imaging to achieve this. With this new understanding, we aspire to then discover how these systems lead to human diseases when perturbed.

CpG Islands / chromatin / epigenetics / gene regulation & transcription