
EMBO Member
Robert J. Klose
EMBO 2021
Former EMBO Young Investigator (2011)
University of Oxford, United Kingdom
Epigenetic control of gene expression
In my group we strive to understand how gene expression is controlled by chromatin-based and epigenetic systems, with a focus on CpG island elements in vertebrates. We use a multidisciplinary approach leveraging biochemistry, molecular genetics, genomics, and live-cell imaging to achieve this. With this new understanding, we aspire to then discover how these systems lead to human diseases when perturbed.
Keywords
CpG Islands / chromatin / epigenetics / gene regulation & transcription