EMBO Member
Robin C. Allshire
EMBO 1998 | FelC 05–08
Wellcome Centre for Cell Biology, Edinburgh, United Kingdom
The establishment and propagation of centromeres
Each chromosome requires a single centromere and associated kinetochore machinery to ensure its accurate segregation to daughter nuclei. Our objective is to determine how the chromosomal location of centromeres is 'chosen' to direct kinetochore assembly. We aim to unravel how genetic and epigenetic information converge to define centromere location.
Keywords
Chromosome segregation / centromeres / Schizosaccharomyces pombe / heterochromatin / kinetochore / mitosis / ncRNA