EMBO Member
Roel Nusse
EMBO 1988
Stanford University School of Medicine, United States
Wnt signaling and stem cell biology
We are interested in understanding how intercellular signals control embryogenesis and organogenesis. Molecules of the Wnt family regulate numerous decisions that cells make during embryogenesis. Wnt signals also influence how stem cells divide. Unrestrained Wnt signaling, after mutations in Wnt signaling components, is implicated in cancer. Currently, my research focuses on how Wnt sigals influence stem cell self-renewal.
Keywords
Oncogenes / Wnt genes / stem cells / signaling / cancer