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EMBO Member

Roel Nusse

Stanford University School of Medicine | United States

EMBO 1988

Wnt signaling and stem cell biology

We are interested in understanding how intercellular signals control embryogenesis and organogenesis. Molecules of the Wnt family regulate numerous decisions that cells make during embryogenesis. Wnt signals also influence how stem cells divide. Unrestrained Wnt signaling, after mutations in Wnt signaling components, is implicated in cancer. Currently, my research focuses on how Wnt sigals influence stem cell self-renewal.

Keywords: Oncogenes / Wnt genes / stem cells / signaling / cancer

Subject area(s): Cell & Tissue Architecture | Development | Signal Transduction