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EMBO Member

Roland Lill

Philipps-Universit├Ąt, Marburg | Germany

EMBO 2013

Biogenesis of iron-sulfur proteins in eukaryotes

My group is interested in the biogenesis and function of cellular iron-sulfur proteins. We try to understand how eukaryotic cells assemble iron-sulfur clusters and insert them into target apoproteins. Our research also focusses on the molecular basis of diseases associated with genetic defects in iron-sulfur protein biogenesis, and on tightly associated processes such as cellular iron regulation and the maintenance of genome integrity.

Keywords: Iron-sulfur proteins / mitochondrial function and diseases / post-translational modifications / iron and sulfur metabolism / ABC transporters / metal biology / spectroscopy / structural biology

Subject area(s): Cellular Metabolism | Membranes & Transport | Proteins & Biochemistry