Biogenesis of iron-sulfur proteins in eukaryotes
My group is interested in the biogenesis and function of cellular iron-sulfur proteins. We try to understand how eukaryotic cells assemble iron-sulfur clusters and insert them into target apoproteins. Our research also focusses on the molecular basis of diseases associated with genetic defects in iron-sulfur protein biogenesis, and on tightly associated processes such as cellular iron regulation and the maintenance of genome integrity.
Keywords
Iron-sulfur proteins / mitochondrial function and diseases / post-translational modifications / iron and sulfur metabolism / ABC transporters / metal biology / spectroscopy / structural biology