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EMBO Member

Rolf Zeller

University of Basel | Switzerland

EMBO 2006

Signaling systems in mouse limb bud organogenesis

My group studies how embryonic cell send, receive and integrate signaling information. We combine mouse molecular genetics with biochemical approaches and mathematical simulations of the self-regulatory signaling networks that regulate limb bud organogenesis. We apply the knowledge gained to engineering of cartilage tissue and understanding the molecular alterations underlying evolutionary diversification of limbs and congenital malformations.

Keywords: Embryonic signalling / developmental engineering / limb development / mouse molecular genetics / signal antagonists

Subject area(s): Development | Genomic & Computational Biology | Signal Transduction