Signaling systems in mouse limb bud organogenesis
My group studies how embryonic cell send, receive and integrate signaling information. We combine mouse molecular genetics with biochemical approaches and mathematical simulations of the self-regulatory signaling networks that regulate limb bud organogenesis. We apply the knowledge gained to engineering of cartilage tissue and understanding the molecular alterations underlying evolutionary diversification of limbs and congenital malformations.
Keywords
Embryonic signalling / developmental engineering / limb development / mouse molecular genetics / signal antagonists