EMBO Associate Member
Ronald M. Evans
EMBO 2006
Salk Institute for Biological Studies, La Jolla, United States
Nuclear receptors and hormone signaling
The discovery of steroid receptors and, subsequently, the family of orphan nuclear receptors provides a molecular approach to study metabolic regulation by fat-soluble hormones, vitamins, and dietary lipids. I am interested in the origins of physiology and the molecular genetics of muscle performance, metabolic disease, inflammation (including atherosclerosis and diabetes), and cancer and using this information to devise small-molecule therapy.
Keywords
Nuclear hormone receptors / metabolic disease / transcriptional control / steroid hormones / molecular medicine / chromatin