Università di Padova | Italy
My group has been traditionally focused on the study of mitochondrial calcium homeostasis, and its role in physiology and disease. In 2011 we molecularly characterized the mitochondrial Ca2+ uptake pathway, identifying the long-sought mitochondrial calcium uniporter (MCU). This molecular information allows now to investigate the structure/function relationship of this novel channel and its function in cultured cells and whole animals.
Keywords: Mitochondria / calcium signalling / cell death / metabolism / ion channels