1936 – 2022
Development of Fluorecence Correlation Spectroscopy (FCS) starting 1968. First detection and analysis of single molecules at room temperature by FCS, application of FCS for high throughput screening by Evotec,Ltd.1993. FCS as tool for measuring Brownian motion and flow, for analysis of chemical relaxation in solution and single cells. Analysis of single photon emitters. High accuracy single molecule DNA sequencing.
Keywords: Structure & dynamics of biopolymers in solution / biological recognition / nucleic acid protein interactions / fluorescence relaxation & correlation spectroscopy