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EMBO Global Investigator

Sandeep Eswarappa

Indian Institute of Science, Bangalore | India

GIN 2022–2025

Translational recoding of stop codons

During translation of certain mRNAs, stop codons are read as sense codons resulting in the continuation of translation instead of termination. Our laboratory is interested in understanding the mechanism and physiological significance of such stop codon recoding (or readthrough) events in mammals. We also use the insights gained from these studies to achieve therapeutic induction of readthrough across disease-causing premature stop codons.

Keywords: Codon / RNA / translation / readthrough / nonsense mutation

Subject area(s): Molecular Medicine | Proteins & Biochemistry | RNA