Programmed genome elimination in Paramecium
Our team studies the remarkable process of small-RNA-guided DNA elimination that occurs during development in the eukaryote Paramecium, in which at least a third of the genome is reproducibly removed. Our efforts aim to understand the mechanisms that control these events, as well as the evolutionary trajectories of the eliminated sequences. Our approach combines molecular and cellular genetics, biochemistry and large-scale genomic strategies.
Keywords
Chromatin / genome dynamics / transposable elements / small RNAs / evolution / epigenetics / genome elimination / ciliate