EMBO Member
Sandrine Etienne-Manneville
EMBO 2015
Former EMBO Young Investigator (2008)
Institut Pasteur, Paris, France
Cell polarity, migration, invasion
We inverstigate the molecular mechanisms controlling cell polarity and directed migration in normal cells to determine which molecular alterations can affect the cell invasive properties during oncogenesis. our research focuses on astrocytes, which are major brain glial cells and gliomas. We aim to elucidate the role of the cytoskeletal networks in cell mechanical properties and signaling pathways that promote cancer progression.
Keywords
Cell polarity / cell migration / cell adhesion / cytoskeleton / mechanotransduction / intermediate filaments / microtubules