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EMBO Member

Sara Sigismund

Università degli Studi, Milano | Italy

EMBO 2022

Organelle communication regulates EGFR signalling

My long-standing research goal is to understand the role of endocytosis in the regulation of growth factor receptor signalling in physiology and cancer. My work led to the discovery of a novel mechanism of non-clathrin endocytosis, involving the communication between different cellular organelles and the direct crosstalk between growth factor receptor signalling and mitochondrial metabolic functions.

Keywords: Non-clathrin endocytosis / ubiquitin / signalling / cancer / epidermal growth factor receptor (EGFR) / membrane contact sites / organelle communication

Subject area(s): Membranes & Transport | Molecular Medicine | Proteins & Biochemistry | Signal Transduction