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EMBO Member

Saulius Klimašauskas

Vilnius University, Vilnius | Lithuania

EMBO 2017

Mechanisms and engineering of DNA methylases

Besides our long standing interest in structural and mechanistic aspects of AdoMet-dependent enzymes, our efforts are now focussed on structure-based engineering of the DNA and RNA methyltransferase-catalyzed reactions and design of molecular tools for analysis of epigenetic regulation in mammalian organisms.

Keywords: DNA methylation / enzyme-cofactor engineering / epigenomic tools / methyltransferase mechanisms / chemo-enzymatic labeling of biopolymers

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Genomic & Computational Biology | Proteins & Biochemistry