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EMBO Member

Seamus J. Martin

Smurfit Institute, Dublin | Ireland

EMBO 2009

Cell death and inflammation

My research is focused on understanding how divergent modes of cell death (apoptosis, necrosis, necroptosis) are regulated and the inflammatory consequences thereof. I have a particular interest in molecules that are released from necrotic cells to drive inflammation (called DAMPs) and we are currently working on the hypothesis that members of the extended IL-1 family are the canonical DAMPs.

Keywords: Apoptosis / Inflammation / caspases / IL-1 family / cytotoxic T cells / proteases / cell death

Subject area(s): Differentiation & Death | Immunology | Signal Transduction