Cell death and inflammation
My research is focused on understanding how divergent modes of cell death (apoptosis, necrosis, necroptosis) are regulated and the inflammatory consequences thereof. I have a particular interest in molecules that are released from necrotic cells to drive inflammation (called DAMPs) and we are currently working on the hypothesis that members of the extended IL-1 family are the canonical DAMPs.
Keywords
Apoptosis / Inflammation / caspases / IL-1 family / cytotoxic T cells / proteases / cell death