EMBO Associate Member
Sean J. Morrison
EMBO 2023
University of Texas Southwestern Medical Center, Dallas, United States
Stem cell self-renewal and cancer cell replication
We study mechanisms that regulate stem cell function in adult tissues and the ways in which those mechanisms get hijacked by cancer cells to enable tumor formation. We identified mechanisms that distinguish stem cell self-renewal from progenitor proliferation as well as the locations and cellular compositions of niches for adult hematopoietic stem cells, including the Leptin Receptor expressing stromal cells that regulate the bone marrow niche.
Keywords
Stem cells / self-renewal / perivascular niche / leptin receptor-positive stromal cells / tumorigenic cells / metastasis / oxidative stress