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EMBO Associate Member

Sean J. Morrison

University of Texas Southwestern Medical Center, Dallas | United States

EMBO 2023

Stem cell self-renewal and cancer cell replication

We study mechanisms that regulate stem cell function in adult tissues and the ways in which those mechanisms get hijacked by cancer cells to enable tumor formation. We identified mechanisms that distinguish stem cell self-renewal from progenitor proliferation as well as the locations and cellular compositions of niches for adult hematopoietic stem cells, including the Leptin Receptor expressing stromal cells that regulate the bone marrow niche.

Keywords: Stem cells / self-renewal / perivascular niche / leptin receptor-positive stromal cells / tumorigenic cells / metastasis / oxidative stress

Subject area(s): Cellular Metabolism | Development | Differentiation & Death | Molecular Medicine