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EMBO Member

Sean Munro

MRC LMB, Cambridge | United Kingdom

EMBO 1997 | Council 01–03 | Council 04–06 | WisC 14–18

The organisation of membrane traffic in the Golgi

The accuracy of membrane traffic depends on organelles having an 'identity' by which they can be recognised. This identity is defined by organelle-specific G proteins and phosphoinositide lipids. Focusing on the Golgi apparatus, we investigate how G proteins are activated in a spatially restricted manner, and identify the cytosolic proteins that then recognise them to direct accurate membrane traffic.

Keywords: Secretory pathway / Golgi apparatus / small G proteins / coiled-coil proteins

Subject area(s): Membranes & Transport | Proteins & Biochemistry